MHC2 Metabolism Folder 1 MTORC1 AMPK MTORC2 AMP/ATPratio ↑ Glycolysis OXPHOS MTOR LKB1 HIF1A Transcription factors Folder 2 IRF4 NFKB IRF3 AP1 CREB IRF7 Output Cytokines Folder 3 IFNB IL1BOUT IL10OUT IL12OUT IL6OUT IL18OUT IL33OUT IFNABOUT TNF-α OUT MR DECTIN1 DECTIN2 CLEC10A MINCLE Phagocytosis Folder 4 PHAGOSOME PROCESSING PHAGO TLRs Folder 6 TLR4 TLR2 TLR3 TLR7 TLR8 TLR9 TLR4END Cytokine Receptors Folder 7 IFNGR CSF2RA IL1R IL4RA IL10R TNF-αR Nutrients Folder 8 GLC FA O2 Antigens Folder 10 ICE IGAC IGGC IC3B Antigens 2 Folder 11 LPSE LP DSRNA SSRNA CPGDNA Cytokines Folder 12 IFNGE GMCSFE IL1BE IL4E IL10E TNF-α E Downstream Proteins Folder 13 STAT1 SOCS1 STAT3 STAT5 NEMOIKKAB CARD9 AKT PKC PPARG KLF4 STAT6 JMJD3 TBK1IKKI ERK MKK12 PI3K MYD88 IRAK4 IRAK12 TRAF6 TAB23TAK RIP1 MKK36 MKK47 JNK CJUN CFOS TRIF TRAF3 IKKA WAVE WASP RAC ITAM SYK CA DAP12 FGR VAV CDC42 PLC LYN FYN TRAF2 CIT DSRNA CIT SSRNA P38 TAK1/2/3 JNK/MAPK ERK1/2 MSK1/2 GSK3B AKT3 AKT1 SOCS3 HCK RiG-1 MAVS TRADD NEMOTBKIKKE Phagocytosis receptors Extracellular Stimuli TLRs Cytokine Receptors Downstream Signals Phagocytosis Mediators Metabolism Transcription factors Secreted Cytokines Phagocytosis receptors Folder 5 FCGR FCAR CD11BCD18